Dose-finding designs for cumulative toxicities using multiple constraints
نویسندگان
چکیده
منابع مشابه
Dose-finding designs using a novel quasi-continuous endpoint for multiple toxicities
The aim of a phase I oncology trial is to identify a dose with an acceptable safety profile. Most phase I designs use the dose-limiting toxicity, a binary endpoint, to assess the unacceptable level of toxicity. The dose-limiting toxicity might be incomplete for investigating molecularly targeted therapies as much useful toxicity information is discarded. In this work, we propose a quasi-continu...
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Identifying the “right” dose is one of the most critical and difficult steps in the clinical development process of any medicinal drug. Its importance cannot be understated: selecting too high a dose can result in unacceptable toxicity and associated safety problems, while choosing too low a dose leads to smaller chances of showing sufficient efficacy in confirmatory trials, thus reducing the c...
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Identifying the “right” dose is one of the most critical and difficult steps in the clinical development process of any medicinal drug. Its importance cannot be understated: selecting too high a dose can result in unacceptable toxicity and associated safety problems, while choosing too low a dose leads to smaller chances of showing sufficient efficacy in confirmatory trials, thus reducing the c...
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ژورنال
عنوان ژورنال: Biostatistics
سال: 2017
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxx059